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GLP-1 & Weight Loss

GLP-1 Side Effects: What to Expect and How to Manage Them

February 5, 20265 min readBy Monaco Health Team
Couple exercising together while on GLP-1 weight loss therapy

Understanding GLP-1 Side Effects

Most GLP-1 side effects are mild to moderate and temporary, especially during the first few weeks of treatment as your body adjusts. Knowing what to expect helps you manage them effectively.

Common Side Effects

Nausea

The most frequently reported side effect. Tips to manage it:

  • Eat smaller, more frequent meals
  • Avoid greasy or heavy foods
  • Stay hydrated
  • Eat slowly and stop when you feel full

Constipation

GLP-1 medications slow gastric emptying, which can affect digestion:

  • Increase fiber intake gradually
  • Drink plenty of water
  • Stay physically active
  • Talk to your doctor about stool softeners if needed

Decreased Appetite

While this is actually part of how the medication works, dramatic appetite loss can be managed:

  • Set reminders to eat regular meals
  • Focus on protein-rich, nutrient-dense foods
  • Don't skip meals entirely

When to Contact Your Doctor

While most side effects are manageable, contact Monaco Health immediately if you experience severe abdominal pain, persistent vomiting, or signs of pancreatitis.

The Good News

For most patients, side effects diminish significantly after the first 4-6 weeks. The gradual dose escalation our medical team uses is specifically designed to minimize discomfort while your body adapts.

Have questions about GLP-1 treatment? Schedule a free consultation to discuss your concerns with our medical team.


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